Spared Pre-irradiated Area in Pustular Lesions Induced by Icotinib Showing Decreased Expressions of CD1a+ Langerhans Cells and FGFR2
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چکیده
منابع مشابه
Langerhans Cells in Skin Lesions of Leprosy
Background: Langerhans cells are important in the pathogenesis of leprosy. A recent study reported that these cells were almost absent in the epidermis overlying lepromatous lesions. Objective: To investigate a possible relationship between the number of Langerhans cells and the histopathologic spectrum of lesions in patients with leprosy. Methods: An immunohistochemical staining for S100 prot...
متن کاملPolyclonal T-Cells Express CD1a in Langerhans Cell Histiocytosis (LCH) Lesions
Langerhans cell histiocytosis (LCH) is a complex and poorly understood disorder that has characteristics of both inflammatory and neoplastic disease. By using eight-colour flow cytometry, we have identified a previously unreported population of CD1a(+)/CD3(+) T-cells in LCH lesions. The expression of CD1a is regarded as a hallmark of this disease; however, it has always been presumed that it wa...
متن کاملlangerhans cells in skin lesions of leprosy
background: langerhans cells are important in the pathogenesis of leprosy. a recent study reported that these cells were almost absent in the epidermis overlying lepromatous lesions. objective: to investigate a possible relationship between the number of langerhans cells and the histopathologic spectrum of lesions in patients with leprosy. methods: an immunohistochemical staining for s100 ...
متن کاملLangerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells.
Langerhans cells (LCs) constitute a subset of DCs that initiate immune responses in skin. Using leprosy as a model, we investigated whether expression of CD1a and langerin, an LC-specific C-type lectin, imparts a specific functional role to LCs. LC-like DCs and freshly isolated epidermal LCs presented nonpeptide antigens of Mycobacterium leprae to T cell clones derived from a leprosy patient in...
متن کاملA CD1a+/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells.
Based on the relative expression of CD11c and CD1a, we have identified three fractions of dendritic cells (DCs) in human peripheral blood, including a direct precursor of Langerhans cells (LCs). The first two fractions were CD11c+ DCs, comprised of a major CD1a+/CD11c+ population (fraction 1), and a minor CD1a-/CD11c+ component (fraction 2). Both CD11c+ fractions displayed a monocyte-like morph...
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ژورنال
عنوان ژورنال: Japanese Journal of Clinical Oncology
سال: 2012
ISSN: 0368-2811,1465-3621
DOI: 10.1093/jjco/hys209